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Angela Vincent

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Angela Vincent
FRS FMedSci
Born
Angela Carmen Vincent

1942 (age 81–82)[1]
Woking,[1] England
Alma materUniversity of London
University College London
AwardsLeslie Oliver Oration
Websitewww.ndcn.ox.ac.uk/team/angela-vincent

Angela Vincent (born 1942)[1] is a British neuroscientist who is emeritus professor at the University of Oxford and a Fellow of Somerville College, Oxford.[2][3][4]

Career and research

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Angela Vincent was born in 1942, the third child of Carmen and Joseph Molony (later KCVO). After St Mary's Convent, Ascot, she studied medicine at King's College London and Westminster Hospital School of Medicine (now merged with Imperial College School of Medicine). After one year as a junior doctor at St Steven's and St Charles' hospitals in London (1966–1967), she obtained an MSc in biochemistry from University College London. In 1967 she married Philip Morse Vincent and they have four children.

After the MSc, she spent three frustrating years trying to fractionate rat brain synaptosomes, until she was taken on by Ricardo Miledi FRS in the biophysics department to work on acetylcholine receptors. During her five years with Miledi, her medical background helped to establish a collaboration on myasthenia gravis with John Newsom-Davis (later FRS); together at the Royal Free Hospital, London, they created a neuroimmunology group that subsequently moved with Newsom-Davis to Oxford when he was appointed action research professor of neurology. After his retirement in 1998, Vincent led the group until 2016. During this time she was head of the department of clinical neurology (2005–2008) at the University of Oxford, president of the International Society of Neuroimmunology (2001–2004), and an associate editor of Brain (2004–2013).[5] Her research group was initially located in the Weatherall Institute of Molecular Medicine at the John Radcliffe Hospital, working on a wide range of biological disciplines encompassing molecular biology, biochemistry, cellular immunology and intracellular neurophysiology. The group's research focused on autoimmune and genetic disorders of the neuromuscular junction, peripheral nerves and more recently the exciting field of central nervous system diseases. The principal autoimmune diseases studied were myasthenia gravis, the Lambert–Eaton myasthenic syndrome, limbic encephalitis, other types of autoimmune encephalitis and acquired neuromyotonia.

Her contributions have been on the roles of antibodies directed against acetylcholine receptors and muscle specific kinase (MuSK) in myasthenia gravis, and glycine receptors or potassium channel-associated proteins LGI1, CASPR2 and Contactin-2 in CNS diseases.

She demonstrated that transfer of antibodies across the placenta from the pregnant woman to the fetus in utero can cause both acute and longer-term neuromuscular and neurodevelopmental abnormalities.

Since 2016 she has been emeritus Professor at Oxford University, emeritus Fellow of Somerville College, and holds an honorary appointment at UCL; she continues to work on neuromuscular disorders and advise young researchers. Her work in Oxford on brain disorders continues under Associate Professor Sarosh Irani and Dr Patrick Waters.

She is a strong supporter of Freedom from Torture (formerly The Medical Foundation for Treatment of Torture Victims) and a Patron of British Pugwash (that brings together scientists and others concerned with international affairs and disarmament).

Awards and honours

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In 2009, she presented the Leslie Oliver Oration at Queen's Hospital.[6] In 2009, she received the medal of the Association of British Neurologists and in 2017, the World Federation of Neurology Scientific Contributions to Neurology award. In 2015, she was awarded the British Neuroscience Association Award for Outstanding Contribution to Neuroscience.[7] In Cologne 2018, she was awarded with J Posner and J Dalmau, the International Prize for Translational Neuroscience of the Gertrud Reemtsma Foundation (formerly the Klaus Joachim Zülch Prize), and in Washington in 2019, the America Epilepsy Society Clinical Science Research Award (with J Dalmau).[8] She received the Inaugural Distinguished Alumni Award, Imperial College, London, 2020 and the Life-time Award of the German Neurological Society (DGN) in 2021. In 2002, she was elected a Fellow of the Academy of Medical Sciences (FMedSci)[9] and in 2011, a Fellow of the Royal Society (FRS).[10]

References

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  1. ^ a b c "VINCENT, Prof. Angela Carmen". Who's Who. Vol. 2017 (online Oxford University Press ed.). Oxford: A & C Black. (Subscription or UK public library membership required.)
  2. ^ "Angela Vincent – Neuroscience (archived copy)". www.neuroscience.ox.ac.uk. Archived from the original on 7 January 2011. Retrieved 16 May 2023.
  3. ^ "Angela Vincent Clinical and Experimental Neuroimmunology (archived copy)". www.imm.ox.ac.uk. Archived from the original on 2 May 2008. Retrieved 16 May 2023.
  4. ^ Hoch, Werner; McConville, John; Helms, Sigrun; Newsom-Davis, John; Melms, Arthur; Vincent, Angela (2001). "Auto-antibodies to the receptor tyrosine kinase MuSK in patients with myasthenia gravis without acetylcholine receptor antibodies". Nature Medicine. 7 (3): 365–368. doi:10.1038/85520. ISSN 1546-170X. PMID 11231638. S2CID 18641849. Closed access icon
  5. ^ "Angela Vincent". www.imm.ox.ac.uk. Retrieved 16 May 2023.
  6. ^ "The Second Leslie Oliver Oration". Archived from the original on 31 July 2012. Retrieved 1 July 2010.
  7. ^ "Prizes awarded by the British Neuroscience Association | The British Neuroscience Association". www.bna.org.uk. Retrieved 29 April 2021.
  8. ^ "Angela Vincent". Nuffield Department of Clinical Neurosciences.
  9. ^ The Academy of Medical Sciences, archived from the original on 6 July 2021, retrieved 6 July 2021
  10. ^ The Royal Society, archived from the original on 24 October 2019, retrieved 6 July 2021

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